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InVivoMAb anti-mouse CD22

Research Use Only
BE0011
Bio X Cell
ApplicationsFlow Cytometry, ImmunoPrecipitation, Other Application
Product group Antibodies
ReactivityMouse
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Overview

  • Supplier
    Bio X Cell
  • Product Name
    InVivoMAb anti-mouse CD22
  • Delivery Days Customer
    7
  • Applications
    Flow Cytometry, ImmunoPrecipitation, Other Application
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    Cy34.1
  • Concentration
    4-11 mg/ml
  • Estimated Purity
    >95%
  • Host
    Mouse
  • Isotype
    IgG1
  • Scientific Description
    The Cy34.1 monoclonal antibody reacts with mouse CD22, a member of the SIGLEC family of lectins. CD22 is expressed at high levels on the surface of mature follicular and marginal zone B lymphocytes, B-1 cells, and plasma cells and associates with the B-cell antigen receptor. CD22 mediates B cell adhesion to ligands on endothelial cells in the bone marrow. Additionally, CD22 negatively regulates B cell activation and prevents the development of autoimmune diseases. The Cy34.1 antibody has been shown to augment B cell proliferation in response to LPS or anti-mouse Ig µ chain.
  • Reactivity
    Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Mitotic History Reveals Distinct Stem Cell Populations and Their Contributions to Hematopoiesis. Saewen P et al., 2016 Mar 29, Cell Rep
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  • CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca2+ signaling. Mueller J et al., 2013 Jul 23, Proc Natl Acad Sci U S A
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  • Human CD22 cannot fully substitute murine CD22 functions in vivo, as shown in a new knockin mouse model. Woehner M et al., 2012 Nov, Eur J Immunol
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  • CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation. Efanov A et al., 2010 May, Leukemia
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  • Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo. Duong BH et al., 2010 Jan 18, J Exp Med
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  • Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance. Gross AJ et al., 2009 May 1, J Immunol
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