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InVivoMAb anti-mouse CD22
BE0011
ApplicationsFlow Cytometry, ImmunoPrecipitation, Other Application
Product group Antibodies
ReactivityMouse
Overview
- SupplierBio X Cell
- Product NameInVivoMAb anti-mouse CD22
- Delivery Days Customer7
- ApplicationsFlow Cytometry, ImmunoPrecipitation, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDCy34.1
- Concentration4-11 mg/ml
- HostMouse
- IsotypeIgG1
- Scientific DescriptionThe Cy34.1 monoclonal antibody reacts with mouse CD22, a member of the SIGLEC family of lectins. CD22 is expressed at high levels on the surface of mature follicular and marginal zone B lymphocytes, B-1 cells, and plasma cells and associates with the B-cell antigen receptor. CD22 mediates B cell adhesion to ligands on endothelial cells in the bone marrow. Additionally, CD22 negatively regulates B cell activation and prevents the development of autoimmune diseases. The Cy34.1 antibody has been shown to augment B cell proliferation in response to LPS or anti-mouse Ig µ chain.
- ReactivityMouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Mitotic History Reveals Distinct Stem Cell Populations and Their Contributions to Hematopoiesis. Saewen P et al., 2016 Mar 29, Cell RepRead more
- CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca2+ signaling. Mueller J et al., 2013 Jul 23, Proc Natl Acad Sci U S ARead more
- Human CD22 cannot fully substitute murine CD22 functions in vivo, as shown in a new knockin mouse model. Woehner M et al., 2012 Nov, Eur J ImmunolRead more
- CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation. Efanov A et al., 2010 May, LeukemiaRead more
- Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo. Duong BH et al., 2010 Jan 18, J Exp MedRead more
- Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance. Gross AJ et al., 2009 May 1, J ImmunolRead more
