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InVivoMAb anti-mouse CD317 (BST2, PDCA-1)
BE0311
ApplicationsFlow Cytometry, ImmunoFluorescence, Other Application
Product group Antibodies
ReactivityMouse
Overview
- SupplierBio X Cell
- Product NameInVivoMAb anti-mouse CD317 (BST2, PDCA-1)
- Delivery Days Customer7
- ApplicationsFlow Cytometry, ImmunoFluorescence, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID927
- Concentration4-11 mg/ml
- HostRat
- IsotypeIgG2b
- Scientific DescriptionThe 927 monoclonal antibody reacts with mouse CD317 also known as BST2 and PDCA-1, a 29-33 kDa type II transmembrane glycoprotein. CD317 is expressed exclusively by plasmacytoid dendritic cells and serves as a marker for these cells. CD317 is also sometimes expressed by some tumor cells, including multiple myeloma, renal cell carcinoma, and melanoma cells. The 927 antibody is a useful tool to specifically deplete plasmacytoid dendritic cells when administered in vivo.
- ReactivityMouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Microbiota-Driven Tonic Interferon Signals in Lung Stromal Cells Protect from Influenza Virus Infection. Bradley KC et al., 2019 Jul 2, Cell RepRead more
- Murine Cytomegalovirus Disrupts Splenic Dendritic Cell Subsets via Type I Interferon-Dependent and -Independent Mechanisms. Nash WT et al., 2017, Front ImmunolRead more
- Activation of Plasmacytoid Dendritic Cells in Colon-Draining Lymph Nodes during Citrobacter rodentium Infection Involves Pathogen-Sensing and Inflammatory Pathways Distinct from Conventional Dendritic Cells. Toivonen R et al., 2016 Jun 1, J ImmunolRead more
- Plasmacytoid dendritic cells modulate nonprotective T-cell responses to genital infection by Chlamydia muridarum. Moniz RJ et al., 2010 Apr, FEMS Immunol Med MicrobiolRead more
- Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists. Rajagopal D et al., 2010 Mar 11, BloodRead more
- In vivo biotinylation of the vasculature in B-cell lymphoma identifies BST-2 as a target for antibody-based therapy. Schliemann C et al., 2010 Jan 21, BloodRead more
- Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation. Blasius AL et al., 2006 Sep 1, J ImmunolRead more
