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InVivoMAb anti-mouse CD40L (CD154)

Research Use Only
BE0017-1
Bio X Cell
ApplicationsWestern Blot, Neutralisation/Blocking
Product group Antibodies
ReactivityMouse
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Overview

  • Supplier
    Bio X Cell
  • Product Name
    InVivoMAb anti-mouse CD40L (CD154)
  • Delivery Days Customer
    7
  • Applications
    Western Blot, Neutralisation/Blocking
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    MR-1
  • Concentration
    4-11 mg/ml
  • Host
    Hamster
  • Isotype
    IgG
  • Scientific Description
    The MR-1 monoclonal antibody reacts with mouse CD154 also known as CD40 ligand. CD154 exists as a 39 kDa accessory molecule and belongs to the TNF superfamily of cytokines. CD154 is primarily expressed on the surface of activated CD4+ T lymphocytes but can also be expressed by platelets, mast cells, macrophages, basophils, NK cells, B lymphocytes, CD8+ T lymphocytes as well as non-hematopoietic cells including smooth muscle cells, endothelial cells, and epithelial cells. CD154 signals through CD40 and is thought to play a key role in T and B lymphocyte costimulation. The MR-1 monoclonal antibody has been reported to inhibit in vitro activation of B lymphocytes by blocking the binding of CD154 with CD40 on T helper cells as well as inhibit the formation of germinal centers and disrupt antigen-specific T cell responses. Additionally, the MR-1 antibody blocks interactions of T cells and antigen-presenting cells in vitro and blocks the development of experimental autoimmune disease in vivo.
  • Reactivity
    Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Monitoring T cell-dendritic cell interactions in vivo by intercellular enzymatic labelling. Pasqual G et al., 2018 Jan 25, Nature
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  • CD4 T cells are required for both development and maintenance of disease in a new mouse model of reversible colitis. Brasseit J et al., 2016 May, Mucosal Immunol
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  • PU.1 Expression in T Follicular Helper Cells Limits CD40L-Dependent Germinal Center B Cell Development. Awe O et al., 2015 Oct 15, J Immunol
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  • Spontaneous restoration of transplantation tolerance after acute rejection. Miller ML et al., 2015 Jul 7, Nat Commun
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  • DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance. Conde P et al., 2015 Jun 16, Immunity
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  • Differential requirement for IL-2 and IL-15 during bifurcated development of thymic regulatory T cells. Marshall D et al., 2014 Dec 1, J Immunol
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  • Epitope-specific regulation of memory programming by differential duration of antigen presentation to influenza-specific CD8(+) T cells. Ballesteros-Tato A et al., 2014 Jul 17, Immunity
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  • Candida-elicited murine Th17 cells express high Ctla-4 compared with Th1 cells and are resistant to costimulation blockade. Krummey SM et al., 2014 Mar 1, J Immunol
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  • Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype. Baumjohann D et al., 2013 Mar 21, Immunity
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  • MHC class Ib-restricted CD8 T cells differ in dependence on CD4 T cell help and CD28 costimulation over the course of mouse polyomavirus infection. Hofstetter AR et al., 2012 Apr 1, J Immunol
    Read more

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