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InVivoMAb anti-mouse IL-1 R (CD121a)
BE0256
Overview
- SupplierBio X Cell
- Product NameInVivoMAb anti-mouse IL-1 R (CD121a)
- Delivery Days Customer7
- ApplicationsNeutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDJAMA-147
- Concentration4-11 mg/ml
- Estimated Purity>95%
- HostHamster
- IsotypeIgG
- Scientific DescriptionThe JAMA-147 monoclonal antibody reacts with mouse IL-1 receptor (IL-1 R) type 1 also known as CD121a. IL-1 R is an 80 kDa transmembrane glycoprotein and a member of the immunoglobulin superfamily. The receptor is expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. IL-1 R type 1 can bind both IL-1α and IL-1β. Upon ligand binding the type I receptor mediates all the known IL-1 biological responses.
- ReactivityMouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- IL-1alpha Mediates Innate and Acquired Resistance to Immunotherapy in Melanoma. Singh S et al., 2021 Apr 15, J ImmunolRead more
- Naive CD8 T cell IFNgamma responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5. Kongsomboonvech AK et al., 2020 Aug, PLoS PathogRead more
- Systemic dysfunction and plasticity of the immune macroenvironment in cancer models. Allen BM et al., 2020 Jul, Nat MedRead more
- Autophagy deficiency in myeloid cells exacerbates eosinophilic inflammation in chronic rhinosinusitis. Choi GE et al., 2018 Mar, J Allergy Clin ImmunolRead more
- Inflammatory memory sensitizes skin epithelial stem cells to tissue damage. Naik S et al., 2017 Oct 26, NatureRead more
- Cutaneous Leishmaniasis Induces a Transmissible Dysbiotic Skin Microbiota that Promotes Skin Inflammation. Gimblet C et al., 2017 Jul 12, Cell Host MicrobeRead more
- IL-1-induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation. Lin CC et al., 2016 Feb 8, J Exp MedRead more
- IL-17 drives psoriatic inflammation via distinct, target cell-specific mechanisms. Ha HL et al., 2014 Aug 19, Proc Natl Acad Sci U S ARead more
