InVivoMAb anti-mouse IL-21R

Bio X Cell

InVivoMAb anti-mouse IL-21R

7

Neutralisation/Blocking

Research Use Only

Monoclonal

4A9

4-11 mg/ml

Rat

IgG2a

The 4A9 monoclonal antibody reacts with mouse IL-21 receptor (IL-21 R) also known as CD360. IL-21 R is a member of the type 1 cytokine receptor family that forms a functional heterodimeric receptor complex with the common gamma chain (CD132). IL-21 R is expressed on both resting and activated B cells, T cells, NK cells and dendritic cells. Upon IL-21 binding, IL-21 R activates downstream Jak-1, Jak-3, STAT1, STAT3 and STAT 5 signal transduction pathways to induce the proliferation and differentiation of T lymphocytes, B lymphocytes, and NK cells. The 4A9 antibody has been shown to block the biological activity of IL-21 R in vivo.

Mouse

2°C to 8°C

12352203