Product image
Product image
InVivoMAb anti-mouse IL-23 (p19)
BE0313
ApplicationsWestern Blot, Neutralisation/Blocking
Product group Antibodies
ReactivityMouse
Overview
- SupplierBio X Cell
- Product NameInVivoMAb anti-mouse IL-23 (p19)
- Delivery Days Customer7
- ApplicationsWestern Blot, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDG23-8
- Concentration4-11 mg/ml
- HostRat
- IsotypeIgG1
- Scientific DescriptionThe G23-8 monoclonal antibody reacts with the p19 subunit of mouse IL-23. IL-23 is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages. IL-23 has been shown to enhance IFNγ production by memory T cells. Additionally, mouse IL-23 induces the proliferation of memory T cells (but not naive T cells), whereas IL-12 has no effect on memory cells. Mouse IL-23 (but not IL-12) can also activate mouse memory T cells to produce the potent proinflammatory cytokine IL-17. IL-23 has been shown to be upregulated in certain autoimmune diseases and promote immunity in response to some viral and mycobacterial infections. The G23-8 antibody can specifically neutralize IL-23 bioactivity with no effect on IL-12 p70 bioactivity.
- ReactivityMouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- IL-23 secreted by myeloid cells drives castration-resistant prostate cancer. Calcinotto A et al., 2018 Jul, NatureRead more
- IL-10-producing intestinal macrophages prevent excessive antibacterial innate immunity by limiting IL-23 synthesis. Krause P et al., 2015 May 11, Nat CommunRead more
- IL-17-producing gammadelta T cells and neutrophils conspire to promote breast cancer metastasis. Coffelt SB et al., 2015 Jun 18, NatureRead more
- High-mobility group box 1 (HMGB1)-Toll-like receptor (TLR)4-interleukin (IL)-23-IL-17A axis in drug-induced damage-associated lethal hepatitis: Interaction of gammadelta T cells with macrophages. Wang X et al., 2013 Jan, HepatologyRead more
- Tumor-infiltrating IL-17-producing gammadelta T cells support the progression of tumor by promoting angiogenesis. Wakita D et al., 2010 Jul, Eur J ImmunolRead more
- Functional relevance of the IL-23-IL-17 axis in lungs in vivo. Ivanov S et al., 2007 Apr, Am J Respir Cell Mol BiolRead more
