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InVivoMAb anti-mouse IL-25
BE0394
Overview
- SupplierBio X Cell
- Product NameInVivoMAb anti-mouse IL-25
- Delivery Days Customer7
- ApplicationsNeutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID2C3
- Concentration4-11 mg/ml
- Estimated Purity>95%
- HostMouse
- IsotypeIgG1
- Scientific DescriptionThe 2C3 monoclonal antibody reacts with mouse IL-25, also known as IL-17E and is a member of the IL-17 family of cytokines. IL-25 is a potent activator of type-2 immune responses and induces the expression of IL-4, IL-5, and IL-13. IL-25 is expressed in several tissues, including lung, stomach, small intestine, and colon and in cell types such as macrophages and epithelial cells in the gut, Th2 cells, mast cells, and NKT cells. IL-25 mediates its biological effects through the receptor IL-17BR, which forms a receptor complex with IL-17RA, both being essential for IL-25 effector functions. IL-25-induced inflammation is typically characterized by elevated levels of type-2 cytokines and serum IgE and IgG1. IL-25 plays a role in Th2 type inflammatory diseases, such as asthma, ulcerative colitis, and atopic dermatitis. The 2C3 antibody has been shown to neutralize IL-25 in vivo and improve pathology in mouse models of colitis and asthma.
- ReactivityMouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Prevention of food allergy development and suppression of established food allergy by neutralization of thymic stromal lymphopoietin, IL-25, and IL-33. Khodoun MV et al., 2018 Jan, J Allergy Clin ImmunolRead more
- Blocking IL-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13. Camelo A et al., 2012 Nov, J GastroenterolRead more
- Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma. Ballantyne SJ et al., 2007 Dec, J Allergy Clin ImmunolRead more
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Product group Antibodies
References
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