InVivoMab anti-mouse IL-3

Melanoma induced immunosuppression is mediated by hematopoietic dysregulation. Kamran N et al., 2018, Oncoimmunology

IL-3 contributes to development of lupus nephritis in MRL/lpr mice. Renner K et al., 2015 Nov, Kidney Int

The STAT5-GATA2 pathway is critical in basophil and mast cell differentiation and maintenance. Li Y et al., 2015 May 1, J Immunol

Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade. Leyva-Castillo JM et al., 2013, Nat Commun

Sequential engagement of FcepsilonRI on Mast Cells and Basophil Histamine H(4) Receptor and FcepsilonRI in Allergic Rhinitis. Shiraishi Y et al., 2013 Jan 15, J Immunol

Antibodies and IL-3 support helminth-induced basophil expansion. Herbst T et al., 2012 Sep 11, Proc Natl Acad Sci U S A

IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen. Ohmori K et al., 2009 Mar 1, J Immunol

CD48 is an allergen and IL-3-induced activation molecule on eosinophils. Munitz A et al., 2006 Jul 1, J Immunol

Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. Min B et al., 2004 Aug 16, J Exp Med

T cell-derived IL-3 induces the production of IL-4 by non-B, non-T cells to amplify the Th2-cytokine response to a non-parasite antigen in Schistosoma mansoni-infected mice. Kullberg MC et al., 1996 Feb 15, J Immunol