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InVivoMAb anti-mouse IL-7Ralpha (CD127)
BE0065
ApplicationsFlow Cytometry, Neutralisation/Blocking
Product group Antibodies
ReactivityMouse
Overview
- SupplierBio X Cell
- Product NameInVivoMAb anti-mouse IL-7Ralpha (CD127)
- Delivery Days Customer7
- ApplicationsFlow Cytometry, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDA7R34
- Concentration4-11 mg/ml
- Estimated Purity>95%
- HostRat
- IsotypeIgG2a
- Scientific DescriptionThe A7R34 monoclonal antibody reacts with mouse IL-7Rα also known as CD127. IL-7Rα is a 60-90 kDa type I transmembrane glycoprotein expressed on immature B cells, thymocytes, peripheral T cells, and bone marrow stromal cells. IL-7Rα forms a heterodimer with the common γ chain (γc or CD132) and upon ligation of IL-7 plays important roles in T and B cell development, and T cell homeostasis. Thymic Stromal Lymphopoietin (TSLP) also binds to IL-7Rα as a complex with the TSLPR chain to trigger activation of dendritic cells, and is also involved in B cell development, allergy and autoimmunity. The A7R34 antibody has been shown to block IL-7Rα signaling when administered in vivo.
- ReactivityMouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Active suppression of intestinal CD4(+)TCRalphabeta(+) T-lymphocyte maturation during the postnatal period. Torow N et al., 2015 Jul 21, Nat CommunRead more
- ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling. Goossens S et al., 2015 Jan 7, Nat CommunRead more
- Effector CD4 T-cell transition to memory requires late cognate interactions that induce autocrine IL-2. McKinstry KK et al., 2014 Nov 5, Nat CommunRead more
- ADAM17 limits the expression of CSF1R on murine hematopoietic progenitors. Becker AM et al., 2015 Jan, Exp HematolRead more
- Opposing effects of CTLA4 insufficiency on regulatory versus conventional T cells in autoimmunity converge on effector memory in target tissue. Devarajan P et al., 2014 Nov 1, J ImmunolRead more
- Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis. Le Saout C et al., 2014 Mar, PLoS PathogRead more
- Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Satpathy AT et al., 2013 Sep, Nat ImmunolRead more
- Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues. Gratz IK et al., 2013 May 1, J ImmunolRead more
- IL7Ralpha contributes to experimental autoimmune encephalomyelitis through altered T cell responses and nonhematopoietic cell lineages. Ashbaugh JJ et al., 2013 May 1, J ImmunolRead more
- A major role for Bim in regulatory T cell homeostasis. Chougnet CA et al., 2011 Jan 1, J ImmunolRead more
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Product group Antibodies
References
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