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InVivoMAb anti-mouse TIGIT
BE0274
ApplicationsFlow Cytometry, Other Application
Product group Antibodies
ReactivityMouse
Overview
- SupplierBio X Cell
- Product NameInVivoMAb anti-mouse TIGIT
- Delivery Days Customer7
- ApplicationsFlow Cytometry, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID1G9
- Concentration4-11 mg/ml
- Estimated Purity>95%
- HostMouse
- IsotypeIgG1
- Scientific DescriptionThe 1G9 monoclonal antibody reacts with mouse TIGIT (T cell immunoreceptor with Ig and ITIM domains). TIGIT is a 26 kDa, type I transmembrane protein and a member of the poliovirus receptor (PVR) family. TIGIT has been found to be expressed on follicular T helper cells in mice while in humans it’s expressed by many T cell subsets including activated T cells, follicular T helper cells, memory T cells, and regulatory T cells as well as on NK cells. TIGIT can interact with certain members of the PVR and PVR-like families, including PVR, PVRL2, PVRL3, CD155, and CD112. TIGIT is thought to negatively regulate NK and T cell activation. Binding of TIGIT on T cells by dendritic cells results in their differentiation into a tolerogenic phenotype, with increased secretion of IL-10 and diminished production of IL-12. TIGIT knock-out mice are more susceptible to autoimmune disease.
- ReactivityMouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- TIGIT limits immune pathology during viral infections. Schorer M et al., 2020 Mar 9, Nat CommunRead more
- Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity. Dixon KO et al., 2018 Apr 15, J ImmunolRead more
- Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy. Burton BR et al., 2014 Sep 3, Nat CommunRead more
- The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions. Chan CJ et al., 2014 May, Nat ImmunolRead more
- Agonistic anti-TIGIT treatment inhibits T cell responses in LDLr deficient mice without affecting atherosclerotic lesion development. Foks AC et al., 2013, PLoS OneRead more
- Cutting edge: TIGIT has T cell-intrinsic inhibitory functions. Joller N et al., 2011 Feb 1, J ImmunolRead more