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InVivoPlus anti-mouse TNFalpha

Research Use Only
BP0058
Bio X Cell
ApplicationsWestern Blot, Neutralisation/Blocking
Product group Antibodies
ReactivityMouse
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Overview

  • Supplier
    Bio X Cell
  • Product Name
    InVivoPlus anti-mouse TNFalpha
  • Delivery Days Customer
    7
  • Applications
    Western Blot, Neutralisation/Blocking
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    XT3.11
  • Concentration
    4-11 mg/ml
  • Host
    Rat
  • Isotype
    IgG1
  • Scientific Description
    The XT3.11 monoclonal antibody reacts with mouse TNFα (tumor necrosis factor-alpha) a multifunctional proinflammatory cytokine. TNFα exists as a soluble 17 kDa monomer, which forms homotrimers in circulation or as a 26 kDa membrane-bound form. TNFα belongs to the TNF superfamily of cytokines and signals through its two receptors, TNFR1 and TNFR2 which can be activated by both the soluble trimeric and membrane-bound and forms of TNFα. TNFα is primarily produced by macrophages in response to foreign antigens such as bacteria (lipopolysaccharides), viruses, and parasites as well as mitogens and other cytokines but can also be expressed by monocytes, neutrophils, NK cells, CD4 T cells and some specialized dendritic cells. TNFα is known to play key roles in a wide spectrum of biological processes including immunoregulation, cell proliferation, differentiation, apoptosis, antitumor activity, inflammation, anorexia, cachexia, septic shock, hematopoiesis, and viral replication. TNFα dysregulation has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Mouse and human TNFα share 79% amino acid sequence identity however, mouse TNFα is glycosylated while human TNFα is not. TNFα knockout animals display defects in response to bacterial infection, characterized by defects in forming organized follicular dendritic cell networks and germinal centers with a lack of primary B cell follicles.
  • Reactivity
    Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • The probacterial effect of type I interferon signaling requires its own negative regulator USP18. Shaabani N et al., 2018 Sep 28, Sci Immunol
    Read more
  • Cutting edge: NF-kappaB p65 and c-Rel control epidermal development and immune homeostasis in the skin. Grinberg-Bleyer Y et al., 2015 Mar 15, J Immunol
    Read more
  • Effector T cells boost regulatory T cell expansion by IL-2, TNF, OX40, and plasmacytoid dendritic cells depending on the immune context. Baeyens A et al., 2015 Feb 1, J Immunol
    Read more
  • Depletion of regulatory T cells in a hapten-induced inflammation model results in prolonged and increased inflammation driven by T cells. Christensen AD et al., 2015 Mar, Clin Exp Immunol
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  • IL-21 promotes late activator APC-mediated T follicular helper cell differentiation in experimental pulmonary virus infection. Yoo JK et al., 2014, PLoS One
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  • Production and differentiation of myeloid cells driven by proinflammatory cytokines in response to acute pneumovirus infection in mice. Maltby S et al., 2014 Oct 15, J Immunol
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  • Soluble, but not transmembrane, TNF-alpha is required during influenza infection to limit the magnitude of immune responses and the extent of immunopathology. DeBerge MP et al., 2014 Jun 15, J Immunol
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  • Smac mimetics and innate immune stimuli synergize to promote tumor death. Beug ST et al., 2014 Feb, Nat Biotechnol
    Read more
  • Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. Deng L et al., 2014 Feb, J Clin Invest
    Read more
  • Combining regulatory T cell depletion and inhibitory receptor blockade improves reactivation of exhausted virus-specific CD8+ T cells and efficiently reduces chronic retroviral loads. Dietze KK et al., 2013, PLoS Pathog
    Read more

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