InVivoPlus recombinant CTLA-4-Ig (hum/hum)

Functional characterization of human T cell hyporesponsiveness induced by CTLA4-Ig. Rochman Y et al., 2015, PLoS One

Transient combination therapy targeting the immune synapse abrogates T cell responses and prolongs allograft survival in mice. Schroder PM et al., 2013, PLoS One

Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression. Chen Y et al., 2012 Feb 15, J Immunol

Anti-complement component C5 mAb synergizes with CTLA4Ig to inhibit alloreactive T cells and prolong cardiac allograft survival in mice. Raedler H et al., 2011 Jul, Am J Transplant

Dynamic quantification of host Schwann cell migration into peripheral nerve allografts. Whitlock EL et al., 2010 Oct, Exp Neurol

IL-6 and TNF-alpha synergistically inhibit allograft acceptance. Shen H et al., 2009 May, J Am Soc Nephrol