InVivoSIM anti-human integrin alpha4beta1 (VLA-4)

Bio X Cell

InVivoSIM anti-human integrin alpha4beta1 (VLA-4)

7

Functional Assay, Flow Cytometry

Research Use Only

Monoclonal

Natalizumab

4-11 mg/ml

>95%

IgG4

This non-therapeutic biosimilar antibody uses the same variable regions from the therapeutic antibody Natalizumab making it ideal for research use. This Natalizumab biosimilar reacts with human VLA-4 α chain also known as CD49d and integrin alpha 4. VLA-4 is a 150 kDa glycoprotein belonging to the integrin family that is expressed by many cell types including T and B lymphocytes, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, and dendritic cells. Integrin α4 associates with integrin β7 to form integrin α4β7 also known as LPAM-1 as well as integrin β1 (CD29) to form integrin α4β1 also known as VLA-4. Integrin α4 plays roles in adhesion and T cell co-stimulation. Integrin α4 ligands include VCAM-1, MAdCAM-1, and fibronectin.

2°C to 8°C

12352203