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IP6K1 antibody

GTX103949
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse
TargetIP6K1
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Overview

  • Supplier
    GeneTex
  • Product Name
    IP6K1 antibody
  • Delivery Days Customer
    9
  • Antibody Specificity
    Knockdown/Knockout validation was supported by references (PMID:27701146)
  • Application Supplier Note
    WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.22 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID9807
  • Target name
    IP6K1
  • Target description
    inositol hexakisphosphate kinase 1
  • Target synonyms
    ATP:1D-myo-inositol-hexakisphosphate phosphotransferase; IHPK1; inositol hexakisphosphate kinase 1; inositol hexaphosphate kinase 1; insP6 kinase 1; Pi uptake stimulator; PiUS
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ92551
  • Protein Name
    Inositol hexakisphosphate kinase 1
  • Scientific Description
    This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternative splicing occurs for this gene; however, the full-length nature of all transcript variants has not yet been described. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Phosphatidic acid inhibits inositol synthesis by inducing nuclear translocation of kinase IP6K1 and repression of myo-inositol-3-P synthase.
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  • IP6K1 Reduces Mesenchymal Stem/Stromal Cell Fitness and Potentiates High Fat Diet-Induced Skeletal Involution. Boregowda SV et al., 2017 Aug, Stem Cells
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  • Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain. Zhu Q et al., 2017 Jan, Mol Metab
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  • Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis. Zhu Q et al., 2016 Nov 1, J Clin Invest
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  • Inositol hexakisphosphate kinase-1 interacts with perilipin1 to modulate lipolysis. Ghoshal S et al., 2016 Sep, Int J Biochem Cell Biol
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  • Inositol Hexakisphosphate Kinase 1 (IP6K1) Regulates Inositol Synthesis in Mammalian Cells. Yu W et al., 2016 May 13, J Biol Chem
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  • Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1. Rao F et al., 2015 Feb 10, Proc Natl Acad Sci U S A
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  • Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death. Rao F et al., 2014 Nov 11, Proc Natl Acad Sci U S A
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