IP6K1 antibody
GTX103949
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetIP6K1
Overview
- SupplierGeneTex
- Product NameIP6K1 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.22 mg/ml
- ConjugateUnconjugated
- Gene ID9807
- Target nameIP6K1
- Target descriptioninositol hexakisphosphate kinase 1
- Target synonymsIHPK1, PiUS, inositol hexakisphosphate kinase 1, ATP:1D-myo-inositol-hexakisphosphate phosphotransferase, Pi uptake stimulator, inositol hexaphosphate kinase 1, insP6 kinase 1
- HostRabbit
- IsotypeIgG
- Protein IDQ92551
- Protein NameInositol hexakisphosphate kinase 1
- Scientific DescriptionThis gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternative splicing occurs for this gene; however, the full-length nature of all transcript variants has not yet been described. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Lazcano P, Schmidtke MW, Onu CJ, et al. Phosphatidic acid inhibits inositol synthesis by inducing nuclear translocation of kinase IP6K1 and repression of myo-inositol-3-P synthase. J Biol Chem. 2022,298(9):102363. doi: 10.1016/j.jbc.2022.102363Read this paper
- Boregowda SV, Ghoshal S, Booker CN, et al. IP6K1 Reduces Mesenchymal Stem/Stromal Cell Fitness and Potentiates High Fat Diet-Induced Skeletal Involution. Stem Cells. 2017,35(8):1973-1983. doi: 10.1002/stem.2645Read this paper
- Zhu Q, Ghoshal S, Tyagi R, et al. Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain. Mol Metab. 2017,6(1):73-85. doi: 10.1016/j.molmet.2016.11.010Read this paper
- Zhu Q, Ghoshal S, Rodrigues A, et al. Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis. J Clin Invest. 2016,126(11):4273-4288. doi: 10.1172/JCI85510Read this paper
- Ghoshal S, Tyagi R, Zhu Q, et al. Inositol hexakisphosphate kinase-1 interacts with perilipin1 to modulate lipolysis. Int J Biochem Cell Biol. 2016,78:149-155. doi: 10.1016/j.biocel.2016.06.018Read this paper
- Yu W, Ye C, Greenberg ML. Inositol Hexakisphosphate Kinase 1 (IP6K1) Regulates Inositol Synthesis in Mammalian Cells. J Biol Chem. 2016,291(20):10437-44. doi: 10.1074/jbc.M116.714816Read this paper
- Rao F, Xu J, Fu C, et al. Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1. Proc Natl Acad Sci U S A. 2015,112(6):1773-8. doi: 10.1073/pnas.1424642112Read this paper
- Rao F, Xu J, Khan AB, et al. Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death. Proc Natl Acad Sci U S A. 2014,111(45):16005-10. doi: 10.1073/pnas.1417900111Read this paper
Datasheet
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