IPO11 Antibody

Cusabio

IPO11 Antibody

20

ELISA

Research Use Only

Polyclonal

Unconjugated

IPO11

importin 11

RanBP11, importin-11, Ran binding protein 11, imp11, ran-binding protein 11

Rabbit

IgG

Importin-11

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).

Human

-20°C or -80°C

41116161