The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA048353(IRAK1BP1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200)
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA048353(IRAK1BP1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200)
IRAK1BP1 Antibody
CSB-PA048353
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
TargetIRAK1BP1
Overview
- SupplierCusabio
- Product NameIRAK1BP1 Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID134728
- Target nameIRAK1BP1
- Target descriptioninterleukin 1 receptor associated kinase 1 binding protein 1
- Target synonymsActA binding protein 3; AIP70; interleukin-1 receptor-associated kinase 1-binding protein 1; IRAK1-binding protein 1; SIMPL
- HostRabbit
- IsotypeIgG
- Protein IDQ5VVH5
- Protein NameInterleukin-1 receptor-associated kinase 1-binding protein 1
- Scientific DescriptionSIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.
- Storage Instruction-20°C or -80°C
- UNSPSC12352203
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