IRAK4-IN-15 [2667681-85-6]

MedChem Express

IRAK4-IN-15 [2667681-85-6]

10

2667681-85-6

Research Use Only

C25H29FN10

488.56

IRAK4-IN-15 (compound 35) is a potent and selective IRAK4 inhibitor with an IC50 of 0.002 microM. IRAK4-IN-15 shows good human PK predictions with low intrinsic clearance. IRAK4-IN-15 shows great synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib. [1].

CC1=NC=C(C2=NC3=C(NC(C)C)N=C(NC4=CN(C(C5)CC65CN(C)C6)N=C4)N=C3C=C2F)C=N1

12131703