IRAK4-IN-16 [1812188-83-2]

MedChem Express

IRAK4-IN-16 [1812188-83-2]

10

1812188-83-2

Research Use Only

C17H20F2N8O

390.39

IRAK4-IN-16 (compound 4) is a potent IRAK4 (interleukin-1 receptor associated kinase 4) inhibitor, with an IC50 of 2.5 nM. IRAK4-IN-16 shows cytotoxicity activity against OCI-LY10, TMD8, Ramos and HT cells, with IC50 values of 0.2, 0.2, 0.6, and 2.7 microM, respectively[1].

FC(F)C1=NN(C=C1NC(C2=C3N(C=CC(N[C@@H]4CCCNC4)=N3)N=C2)=O)C

12131703