Irdabisant (hydrochloride) [1005398-61-7]
HY-109968A
CAS Number1005398-61-7
Product group Chemicals
Molecular Weight349.86
Overview
- SupplierMedChem Express
- Product NameIrdabisant (hydrochloride) [1005398-61-7]
- Delivery Days Customer10
- CAS Number1005398-61-7
- CertificationResearch Use Only
- Molecular FormulaC18H24ClN3O2
- Molecular Weight349.86
- Scientific DescriptionIrdabisant (CEP-26401) hydrochloride is a selective, orally active and blood-brain barrier (BBB) penetrant histamine H3 receptor (H3R) inverse agonist/inverse agonist with Ki values of 7.2 nM and 2.0 nM for rat H3R and human H3R, respectively. Irdabisant hydrochloride has relatively low inhibitory activity against hERG current with an IC50 of 13.8 microM. Irdabisant hydrochloride has cognition-enhancing and wake-promoting activities in the rat social recognition model. Irdabisant hydrochloride can be used to research schizophrenia or cognitive impairment[1][2].
- SMILESC[C@H](CCC1)N1CCCOC2=CC=C(C(C=C3)=NNC3=O)C=C2.[H]Cl
- UNSPSC12352200