iso-ADP ribose

MedChem Express

iso-ADP ribose

9

Research Use Only

C15H23N5O14P2

559.32

iso-ADP ribose (isoADPr) is a ligand used for protein nucleic acid modification. iso-ADP ribose is a structure comprising parts of two consecutive ADP-ribosyl units within the PAR chain. iso-ADP ribose is the small-molecule ligand for RING finger protein 146 (RNF146) WWE. A single iso-ADP ribose molecule triggers the activation of RNF146 by interacting with the basic Lys61 residue in the RING domain[1][2].

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O[C@@H]4O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]4O)[C@H](O)[C@@H](COP(O)(O)=O)O3

12162000