ISRIB

MedChem Express

ISRIB [548470-11-7]

10

548470-11-7

Research Use Only

98.58

C22H24Cl2N2O4

451.34

ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR) . Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research [1] [2] [3] .

O=C(NC1CCC(NC(COC2=CC=C(Cl)C=C2)=O)CC1)COC3=CC=C(Cl)C=C3

-20°C,2°C to 8°C

12352200