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ISRIB

HY-12495A
MedChem Express
CAS Number548470-11-7
DownloadMSDS
Product group Chemicals
Estimated Purity98.58
Molecular Weight451.34
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Overview

  • Supplier
    MedChem Express
  • Product Name
    ISRIB [548470-11-7]
  • Delivery Days Customer
    10
  • CAS Number
    548470-11-7
  • Certification
    Research Use Only
  • Estimated Purity
    98.58
  • Molecular Formula
    C22H24Cl2N2O4
  • Molecular Weight
    451.34
  • Scientific Description
    ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR) . Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research [1] [2] [3] .
  • SMILES
    O=C(NC1CCC(NC(COC2=CC=C(Cl)C=C2)=O)CC1)COC3=CC=C(Cl)C=C3
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200