ITK inhibitor 6 [2404604-06-2]
HY-146672
CAS Number2404604-06-2
Product group Chemicals
Molecular Weight486.51
Overview
- SupplierMedChem Express
- Product NameITK inhibitor 6 [2404604-06-2]
- Delivery Days Customer10
- CAS Number2404604-06-2
- CertificationResearch Use Only
- Molecular FormulaC28H24F2N4O2
- Molecular Weight486.51
- Scientific DescriptionITK inhibitor 6 (compound 43) is a potent and selective ITK inhibitor with IC50s of 4 nM, 133 nM, 320 nM, 2360 nM, 155 nM for ITK, BTK, JAK3, EGFR, LCK, respectively. ITK inhibitor 6 inhibits phosphorylation of PLCgamma1 and ERK1/2. ITK inhibitor 6 shows antiproliferative activities[1].
- SMILESC=CC(NCCOC1=C2C=C(NC2=CC(CC3=CC=CC=C3)=C1)C4=NNC5=C4C=CC(C(F)F)=C5)=O
- UNSPSC12131703