ITK inhibitor 6 [2404604-06-2]

MedChem Express

ITK inhibitor 6 [2404604-06-2]

10

2404604-06-2

Research Use Only

C28H24F2N4O2

486.51

ITK inhibitor 6 (compound 43) is a potent and selective ITK inhibitor with IC50s of 4 nM, 133 nM, 320 nM, 2360 nM, 155 nM for ITK, BTK, JAK3, EGFR, LCK, respectively. ITK inhibitor 6 inhibits phosphorylation of PLCgamma1 and ERK1/2. ITK inhibitor 6 shows antiproliferative activities[1].

C=CC(NCCOC1=C2C=C(NC2=CC(CC3=CC=CC=C3)=C1)C4=NNC5=C4C=CC(C(F)F)=C5)=O

12131703