ITM2B antibody, Internal

GeneTex

ITM2B antibody, Internal

7

WB: 1-3microg/ml. IHC-P: 2.5microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

0.50 mg/ml

Unconjugated

ITM2B

integral membrane protein 2B

ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, RDGCA, imBRI2, integral membrane protein 2B, ABri/ADan amyloid peptide, BRICHOS domain containing 2B, epididymis secretory sperm binding protein, immature BRI2, transmembrane protein BRI

Goat

IgG

Integral membrane protein 2B

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]

Human

-20°C or -80°C,2°C to 8°C

12352203