Ivacaftor-d9

MedChem Express

Ivacaftor-d9 [1413431-07-8]

10

1413431-07-8

Research Use Only

99.83

C24H19D9N2O3

401.55

Ivacaftor-d9 is a potent CFTR modulator and exhibits an EC50 value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research[1].

CC(C)(C1=CC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=C(C=C1NC(C2=CNC(C=CC=C3)=C3C2=O)=O)O)C

-20°C,2°C to 8°C

12352200