IW927 [389142-48-7]
HY-118922
CAS Number389142-48-7
Product group Chemicals
Estimated Purity99.23
Molecular Weight441.57
Overview
- SupplierMedChem Express
- Product NameIW927 [389142-48-7]
- Delivery Days Customer10
- CAS Number389142-48-7
- CertificationResearch Use Only
- Estimated Purity99.23
- Molecular FormulaC22H23N3O3S2
- Molecular Weight441.57
- Scientific DescriptionIW927 is a photochemically enhanced TNF-alpha-TNFR1 interaction inhibitor that blocks the binding of TNF-alpha to TNFRc1 with an IC50 value of 50 nM. IW927 binds reversibly to the TNFRc1 with weak affinity (Kd = 40-100 microM), covalently modifies the receptor via a photochemical reaction, and does not bind the related cytokine receptors TNFRc2 or CD40. IW927 disrupts TNFalpha-induced IkappaB phosphorylation with an IC50 value of 600 nM. IW927 can be used to develop light-independent inhibitors[1].
- SMILESO=C(C1=CC2=C(C=C(S2)C3=CC=CC(OC)=C3)N1C4=S)N4CCCN5CCOCC5
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200