IWP-O1

MedChem Express

IWP-O1 [2074607-48-8]

10

2074607-48-8

99.81

C26H20N6O

432.48

IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC 50 of 80 pM in L-Wnt-STF cells. IWP-O1 prevents the secretion of Wnt proteins. IWP-O1 suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells [1] .

O=C(CN1N=NC(C2=CC=NC=C2)=C1C3=CC=CC=C3)NC4=NC=C(C5=CC=CC=C5)C=C4

2°C to 8°C

12352200