J-1063 [2374772-46-8]

MedChem Express

J-1063 [2374772-46-8]

10

2374772-46-8

Research Use Only

C24H19N5OS

425.51

J-1063 is a potent, selective and orally active ALK5 inhibitor with an IC50 of 0.039 microM. J-1063 shows anti-fibrotic effect by the inhibition of inflammatory infiltration, collagen deposition, and hepatocytes necrosis. J-1063 has the potential for the research of liver fibrosis[1].

CC1=NC(C2=NN(C=C2C3=CC4=C(S3)C=CN=C4)CC(NC5=CC=CC=C5)=O)=CC=C1

12131703