Jagged-2 (human):Fc (human) (rec.)

AdipoGen Life Sciences

Jagged-2 (human):Fc (human) (rec.)

10

Research Use Only

0.1 mg/ml

>90%

Protein jagged-2

Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development. - Protein. Human Jagged-2 (aa 1-1054) is fused at the C-terminus to the Fc portion of human IgG. Source: HEK 293 cells. Endotoxin content: <0.1EU/microg purified protein (LAL test; Lonza). Lyophilized. Contains PBS + 0.02 % CHAPS. Purity: >90% (SDS-PAGE). Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development.

-20°C,2°C to 8°C

12352202