JAK1-IN-12

MedChem Express

JAK1-IN-12 [2945204-95-3]

14

Research Use Only

C20H23N5O

349.43

JAK1-IN-12 is a selective inhibitor of JAK1, with IC50 of 0.0246 microM. And IC50s of 0.423 microM, 0.410 microM and 1.12 microM for JAK2, JAK3 and TYK2. JAK1-IN-12 promotes hair growth in mice. JAK1-IN-12 can be used for research of immune and inflammatory diseases[1].

O[C@]12C[C@@H](C[C@H]3C2)[C@H](NC4=C(C=CN5)C5=NC=C4C6=CNN=C6)[C@@H](C3)C1

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