JAK1-IN-4 [2091134-35-7]

MedChem Express

JAK1-IN-4 [2091134-35-7]

5

2091134-35-7

Research Use Only

99.26

C26H32FN9O2

521.59

JAK1-IN-4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12.8 microM and >30 microM for JAK1, JAK2, and JAK3, respectively. JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM)[1].

O=C(NC1=CC=CC2=C1NC=C2C3=C(C=NC(NC4=CN(N=C4OC)C)=N3)F)[C@H](N5CCN([C@@H](C5)C)C)C

-20°C,2°C to 8°C

12352200