JBI-589 [2308504-22-3]

MedChem Express

JBI-589 [2308504-22-3]

14

2308504-22-3

Research Use Only

99.75

C29H28FN5O

481.56

JBI-589 is a non-covalent PAD4 isoform-selective inhibitor with oral bioavailability. JBI-589 reduces CXCR2 expression and blocks neutrophil chemotaxis. JBI-589 reduces primary tumor and metastases, and enhances the anti-tumor effect of checkpoint inhibitors. JBI-589 can be used in cancer research[1][2].

CC(N1C(C=C(C=C1)C(N2C[C@@H](CCC2)N)=O)=N3)=C3C4=CC5=CC=CC=C5N4CC6=CC=C(C=C6)F

-20°C,2°C to 8°C

12352200