JBJ-09-063 [2820336-67-0]
HY-147183
CAS Number2820336-67-0
Product group Chemicals
Molecular Weight556.65
Overview
- SupplierMedChem Express
- Product NameJBJ-09-063 [2820336-67-0]
- Delivery Days Customer10
- CAS Number2820336-67-0
- CertificationResearch Use Only
- Molecular FormulaC31H29FN4O3S
- Molecular Weight556.65
- Scientific DescriptionJBJ-09-063 is a mutant-selective allosteric EGFR inhibitor with IC50s of 0.147 nM, 0.063 nM, 0.083 nM and 0.396 nM for EGFR L858R, EGFR L858R/T790M, EGFR L858R/T790M/C797S and EGFRLT/L747S. JBJ-09-063 effectively reduces EGFR, Akt and ERK1/2 phosphorylation. JBJ-09-063 is effective across EGFR tyrosine kinase inhibitor (TKI)-sensitive and resistant models. JBJ-09-063 can be used for researching EGFR-mutant lung cancer[1].
- SMILESO=C(NC1=NC=CS1)C(C2=CC(F)=CC=C2O)N(CC3=C4C=C(C5=CC=C(C6CCN(C)CC6)C=C5)C=C3)C4=O
- UNSPSC12131703