Bio-Connect

JBJ-09-063 [2820336-67-0]

HY-147183
MedChem Express
CAS Number2820336-67-0
Product group Chemicals
Molecular Weight556.65
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Overview

  • Supplier
    MedChem Express
  • Product Name
    JBJ-09-063 [2820336-67-0]
  • Delivery Days Customer
    10
  • CAS Number
    2820336-67-0
  • Certification
    Research Use Only
  • Molecular Formula
    C31H29FN4O3S
  • Molecular Weight
    556.65
  • Scientific Description
    JBJ-09-063 is a mutant-selective allosteric EGFR inhibitor with IC50s of 0.147 nM, 0.063 nM, 0.083 nM and 0.396 nM for EGFR L858R, EGFR L858R/T790M, EGFR L858R/T790M/C797S and EGFRLT/L747S. JBJ-09-063 effectively reduces EGFR, Akt and ERK1/2 phosphorylation. JBJ-09-063 is effective across EGFR tyrosine kinase inhibitor (TKI)-sensitive and resistant models. JBJ-09-063 can be used for researching EGFR-mutant lung cancer[1].
  • SMILES
    O=C(NC1=NC=CS1)C(C2=CC(F)=CC=C2O)N(CC3=C4C=C(C5=CC=C(C6CCN(C)CC6)C=C5)C=C3)C4=O
  • UNSPSC
    12131703