JBJ-09-063 TFA
ORB1982833
Estimated Purity98.00%
Product group Chemicals
Molecular Weight670.67
Overview
- SupplierBiorbyt
- Product NameJBJ-09-063 TFA
- Delivery Days Customer10
- CertificationResearch Use Only
- Estimated Purity98.00%
- Molecular FormulaC33H30F4N4O5S
- Molecular Weight670.67
- Scientific DescriptionJBJ-09-063 TFA is a mutant-selective allosteric EGFR inhibitor with IC50 values of 0.147 nM for EGFR L858R, 0.063 nM for EGFR L858R/T790M, 0.083 nM for EGFR L858R/T790M/C797S, and 0.396 nM for EGFR L747S mutations. It effectively reduces phosphorylation of EGFR, Akt, and ERK1/2, demonstrating efficacy in models both sensitive and resistant to EGFR tyrosine kinase inhibitors (TKI). JBJ-09-063 TFA holds potential for research in EGFR-mutant lung cancer [1].
- Storage Instruction-20°C
- UNSPSC12352200