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ProductsBack/JH-131e-153 [742104-91-2]

JH-131e-153 [742104-91-2]

HY-149489
MedChem Express
CAS Number742104-91-2
DownloadMSDS
Product group Chemicals
Molecular Weight382.53
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Overview

  • Supplier
    MedChem Express
  • Product Name
    JH-131e-153 [742104-91-2]
  • Delivery Days Customer
    14
  • CAS Number
    742104-91-2
  • Certification
    Research Use Only
  • Molecular Formula
    C22H38O5
  • Molecular Weight
    382.53
  • Scientific Description
    JH-131e-153, a diacylglycerol (DAG)-lactone, is a small molecule activator of Munc13-1, targeting the C1 domain. The activation sequence of JH-131e-153 on Munc13-1 is WT>I590~R592A~W588A. The C1 domain of Munc13-1 and protein kinase C (PKC) are homologous in sequence and structure. The activation sequence of JH-131e-153 on Munc13-1 and PKC was PKCalpha>Munc13-1>PKCepsilon. JH-131e-153 regulates neuronal processes through Munc13-1 and can be further used in the study of neurodegenerative diseases[1].
  • SMILES
    CC(C)(C)C(OC[C@@](C/C1=C/CC(CC(C)C)CC(C)C)(CO)OC1=O)=O
  • UNSPSC
    12131703