JH-X-119-01

MedChem Express

JH-X-119-01 [2227368-54-7]

10

2227368-54-7

Research Use Only

99.03

C25H20N6O3

452.46

JH-X-119-01 is a potent and selective interleukin-1 receptor-associated kinases 1 ( IRAK1 ) inhibitor. JH-X-119-01 ameliorates LPS-induced sepsis in mice [1] . JH-X-119-01 inhibits IRAK1 biochemically with an apparent IC 50 of 9 nM while exhibiting no inhibition of IRAK4 at concentrations up to 10 microM [2] .

O=C(C=C)NC1=CC=CC(C(NC2=CC=C(NC(C3=NC(C4=CC=NN4)=CC=C3)=O)C=C2)=O)=C1

-20°C,2°C to 8°C

12352200