JH295 [1311143-71-1]

TargetMol Chemicals

JH295 [1311143-71-1]

14

1311143-71-1

Chemical

Research Use Only

JH295

C18H16N4O2

320.352

JH295 is a highly potent and selective inhibitor of NIMA-related kinase 2 (Nek2), exhibiting irreversible inhibition activity with an IC 50 value of 770 nM. This compound effectively inhibits cellular Nek2 using the alkylation of Cys22. Importantly, JH295 does not exhibit any inhibitory effects toward Cdk1, Aurora B, or Plk1, which are kinases involved in mitotic processes. Furthermore, JH295 has no impact on bipolar spindle assembly or the spindle assembly checkpoint mechanism.

3 years

CCc1nc(C)c(\C=C2/C(=O)Nc3ccc(NC(=O)C#C)cc23)[nH]1

-20°C

12352200