JH295 (hydrate)
HY-116423A
Estimated Purity99.0
Product group Chemicals
Molecular Weight338.36
Overview
- SupplierMedChem Express
- Product NameJH295 (hydrate)
- Delivery Days Customer10
- CertificationResearch Use Only
- Estimated Purity99.0
- Molecular FormulaC18H18N4O3
- Molecular Weight338.36
- Scientific DescriptionJH295 hydrate is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 770 nM. JH295 hydrate inhibits cellular Nek2 via alkylation of Cys22. JH295 hydrate is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint[1]. JH295 (hydrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- SMILESC#CC(NC1=CC2=C(NC(/C2=C\C3=C(C)N=C(CC)N3)=O)C=C1)=O.[H]O[H]
- Storage Instruction-20°C
- UNSPSC12352200