JI6

Biorbyt

JI6

10

856436-16-3

Research Use Only

97.74%

C19H17N3O4S

383.42

JI6 (JAK3 Inhibitor VI) is a potent, selective and orally active FLT3 inhibitor. JI6 exhibits IC50s of ~40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively. JI6 also inhibits c-Kit and JAK3, with IC50s of ~500 and ~250 nM, respectively. JI6 has research value in acute myeloid leukemia.

CS(=O)(O)=O.O=C(/C1=C\C2=CC=CN2)NC(C=C3)=C1C=C3C4=CN=CC=C4

-20°C

12352200