JIP1 antibody

GeneTex

JIP1 antibody

9

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

MAPK8IP1

mitogen-activated protein kinase 8 interacting protein 1

C-Jun-amino-terminal kinase-interacting protein 1; IB1; IB-1; islet-brain 1; JIP1; JIP-1; JNK MAP kinase scaffold protein 1; JNK-interacting protein 1; PRKM8 interacting protein; PRKM8IP

Rabbit

IgG

The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq]

Human, Mouse

2°C to 8°C,-20°C or -80°C

12352203