JJO-1 [16722-44-4]

TargetMol Chemicals

JJO-1 [16722-44-4]

72

Research Use Only

JJO-1

C19H13N3

283.33

JJO-1 is a bi-quinoline that allosterically activates all AMPK alphabetagamma isoforms in vitro except complexes containing the gamma3 subunit. JJO-1 does not directly activate the autoinhibited alpha subunit kinase domain and differs among other known direct activators of AMPK in that allosteric activation occurs only at low ATP concentrations, and is not influenced by either mutation of the gamma subunit adenylate-nucleotide binding sites or deletion of the beta subunit carbohydrate-binding module.

3 years

N(=CC1=NC2=C(C=C1)C=CC=C2)C3=CC4=C(N=C3)C=CC=C4

-20°C

12352200