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JK-P3

HY-108933
MedChem Express
CAS Number942655-44-9
DownloadMSDS
Product group Chemicals
Estimated Purity99.72
Molecular Weight323.352
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Overview

  • Supplier
    MedChem Express
  • Product Name
    JK-P3 [942655-44-9]
  • Delivery Days Customer
    10
  • CAS Number
    942655-44-9
  • Certification
    Research Use Only
  • Estimated Purity
    99.72
  • Molecular Formula
    C18H17N3O3
  • Molecular Weight
    323.352
  • Scientific Description
    JK-P3 is a potent and pan VEGFR2 inhibitor, with IC 50 s of 7.83 microM, 27 microM and 5.18 microM for VEGFR2, FGFR1 and FGFR3, respectively. JK-P3 can inhibit VEGF-A-stimulated VEGFR2 activation and intracellular signalling, also inhibits endothelial monolayer wound closure and angiogenesis, as well as fibroblast growth factor receptor kinase activity in vitro . JK-P3 has anti-angiogenic activity [1] .
  • SMILES
    O=C(NC1=NNC(C2=CC=CC=C2)=C1)C3=CC=C(OC)C(OC)=C3
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200