JK184
M6843
CAS Number315703-52-7
Product group Chemicals
Molecular Weight350.44
Overview
- SupplierAbMole BioScience
- Product NameJK184
- Delivery Days Customer9
- CAS Number315703-52-7
- Category SupplierChemical
- CertificationResearch Use Only
- Molecular FormulaC19H18N4OS
- Molecular Weight350.44
- Scientific DescriptionJK184 is a potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). JK184 exhibits antiproliferative activity in a range of cancer cell lines (GI50 = 3 - 21 nM) and in human xenografts in vivo. JK184 inhibits alcohol dehydrogenase 7 (Adh7) (IC50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro.
- SMILESCCOC1=CC=C(NC2=NC(=CS2)C3=C(C)N=C4C=CC=C[N]34)C=C1
- UNSPSC12352200
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