JMI-105 [2227315-30-0]

MedChem Express

JMI-105 [2227315-30-0]

10

2227315-30-0

Research Use Only

C20H23N3O2

337.42

JMI-105 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-105 inhibits the growth of CQS (3D7; IC50=8.8 microM) and CQR (RKL-9; IC50=14.3 microM) strains of P. falciparum. JMI-105 significantly decreases parasitemia and prolonged host survival in a murine model with P. berghei ANKA infection. JMI-105 has the potential to be used as an anti-malarial agent[1].

CC(C1=CC=C(C)C(OCC2=CN(C3=CC=C(OC)C=C3)N=N2)=C1)C

12131703