JMJD1C antibody

GeneTex

JMJD1C antibody

9

This antibody will not cross-react with JMJD1A or JMJD1B.

WB: 1 - 2 microg/mL. IHC-P: 2.5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

JMJD1C

jumonji domain containing 1C

KDM3C; probable JmjC domain-containing histone demethylation protein 2C; thyroid hormone receptor interactor 8; thyroid receptor-interacting protein 8; TR-interacting protein 8; TRIP8; TRIP-8

Rabbit

IgG

Probable JmjC domain-containing histone demethylation protein 2C

The jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico, and later suggested to be a candidate gene for autism. Like the related proteins JMJD1A and JMJD1B, JMJD1C is a histone H3K9 demethylase implicated in the nuclear hormone receptor-based transcriptional regulation. JMJD1C mRNA is highly expressed in undifferentiated embryonic stem (ES) cells as well as pancreatic islet, diffuse-type gastric cancer, and other tissues and tumors. The JMJD1C gene promoter contain bHLH-, AP-1-, and POU5F1-binding sites, and as preferential expression of POU5F1 has been reported in ES cells, pancreatic islet, and diffuse-type gastric cancer, it has been suggested that POU5F1-mediated expression of JMJD1C reactivates previously silenced genes in ES cells and diffuse-type gastric cancer. At least three isoforms of JMJD1C are known to exist. This antibody will not cross-react with JMJD1A or JMJD1B.

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203