JMJD3/HDAC-IN-1 [2883046-06-6]
HY-156094
Product group Molecular Biology
Overview
- SupplierMedChem Express
- Product NameJMJD3/HDAC-IN-1 [2883046-06-6]
- Delivery Days Customer14
- CAS Number2883046-06-6
- CertificationResearch Use Only
- Molecular FormulaC21H30N6O2
- Molecular Weight398.50
- Scientific DescriptionJMJD3/HDAC-IN-1 (compound A5b) is a dual inhibitor targeting Jumonji domain-containing protein demethylase 3 (JMJD3) and histone deacetylase (HDAC1, IC50=16 nM). JMJD3/HDAC-IN-1 promotes hypermethylation of histone H3K27 and hyperacetylation of H3K9, and also cleaves caspase-7 and PARP to induce apoptosis. JMJD3/HDAC-IN-1 effectively inhibits cancer cell cloning, migration, and invasion[1].
- SMILESO=C(CCCCCNC1=NC(C2=NC=CC=C2)=NC(N3CCCCCC3)=C1)NO
- UNSPSC41115800