JNJ-10198409

MedChem Express

JNJ-10198409 [627518-40-5]

10

627518-40-5

Research Use Only

99.58

C18H16FN3O2

325.34

JNJ-10198409 is a relatively selective, orally active, and ATP competitive PDGF-RTK (platelet-derived growth factor receptor tyrosine kinase) inhibitor (IC50=2 nM). It is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent. JNJ-10198409 has good activity against PDGFR-beta kinase (IC50=4.2 nM) and PDGFR-alpha kinase (IC50=45 nM)[1][2].

COC1=CC2=C(C=C1OC)CC3=C2NN=C3NC4=CC=CC(F)=C4

-20°C

12352200