JNJ-10229570

MedChem Express

JNJ-10229570 [524923-88-4]

10

524923-88-4

Research Use Only

98.0

C22H19N3O2S

389.47

JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R) , which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of 125 I-NDP-alpha-MSH to cells expressing human MC1R and MC5R, with IC 50 values of 270 nM and 200 nM, respectively.

COC1=C(C=CC=C1)C(N(C2=C(C=CC=C2)OC)S/3)=NC3=N\C4=CC=CC=C4

-20°C,2°C to 8°C

12352200