JNJ-16241199

MedChem Express

JNJ-16241199 [604769-01-9]

5

604769-01-9

Research Use Only

99.05

C19H19N5O4S

413.45

JNJ-16241199 (R306465) is an orally active, selective hydroxamate-based histone deacetylase (HDAC) inhibitor, with the IC 50 of 3.3 nM and 23 nM for HDAC1 and HDAC8 , respectively.JNJ-16241199induces histone 3 acetylation and strongly increases the expression of p21 waf1 , cip1 in A2780 ovarian carcinoma cells.JNJ-16241199 induces cell apoptosis and shows anticancer activityin a broad spectrum of human malignancies. JNJ-16241199 can be used for cancer study [1] .

O=S(N(CC1)CCN1C2=NC=C(C(NO)=O)C=N2)(C3=CC=C4C(C=CC=C4)=C3)=O

-20°C,2°C to 8°C

12352200