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ProductsBack/JNJ-39729209 [1160606-90-5]

JNJ-39729209 [1160606-90-5]

HY-120476
MedChem Express
CAS Number1160606-90-5
Product group Chemicals
Molecular Weight455.28
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Overview

  • Supplier
    MedChem Express
  • Product Name
    JNJ-39729209 [1160606-90-5]
  • Delivery Days Customer
    5
  • CAS Number
    1160606-90-5
  • Certification
    Research Use Only
  • Molecular Formula
    C19H11Cl2F3N4S
  • Molecular Weight
    455.28
  • Scientific Description
    JNJ-39729209 is an antagonist for transient receptor potential vanilloid 1 (TRPV1) with pIC50 of 7.9, 8.5, 7.9 and 7.7 for TRPV1 from human, rat, canine and guinea pig. JNJ-39729209 inhibits Capsaicin (HY-10448)-induced hypotension and inhibit thereby hypothermia. JNJ-39729209 exhibits anti-inflammatory and analgesic activities in Carrageenan (HY-125474)- and CFA (HY-153808)-induced thermal hyperalgesia rat models. JNJ-39729209 exhibits anti-cough effects in guinea pigs[1].
  • SMILES
    FC(C1=CC=C(NC2=C3C(SC(CC4=C(Cl)C=CC=C4Cl)=N3)=NC=N2)C=C1)(F)F
  • UNSPSC
    12352200

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