JNJ-39758979 (dihydrochloride)
HY-101189B
Molecular Weight294.22
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameJNJ-39758979 (dihydrochloride)
- Delivery Days Customer10
- Molecular FormulaC11H21Cl2N5
- Molecular Weight294.22
- Scientific DescriptionJNJ-39758979 dihydrochloride is a selective, orally active, and high-affinity histamine H 4 receptor antagonist, with K i s of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H 4 receptor, respectively. JNJ-39758979 dihydrochloride functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 dihydrochloride shows good anti-inflammatory and antipruritic activity [1] [2] .
- SMILESNC1=NC(C(C)C)=CC(N2C[C@H](N)CC2)=N1.[H]Cl.[H]Cl
- UNSPSC12352200